Organoid Model Establishment
The organoid model is a 3D (three-dimensional) cell culture system that is highly similar in cell specificity and function to the source tissue or organ in vivo. These 3D systems can replicate the complex spatial morphology of differentiated tissues ..
Organoid Model Characterization Services
We have the capabilities to perform multi-omics characterization of organoids, including genomic, transcriptomic, proteomic, and histopathological data acquisition. This enables us to provide our
Clinical Drug Sensitivity Test of Tumor Organoids
Organoids offer a personalized treatment strategy for individual patient, encompassing in vitro drug screening and genotyping. This strategy aims to formulate therapeutic drugs and methods customized to each patient's unique disease profile. When integrated into precision medicine, the drug sensitivity of Patient-Derived Organoids (PDOs) can be assessed by analyzing alterations in cell viability and morphology. This information serves as a valuable resource for guiding the clinical prescription of drugs to patients. Current studies indicate a remarkable level of concordance between the drug sensitivity results from PDOs and those observed in clinical medication. In a groundbreaking study published in Science, Vlachogiannis G and his team conducted in vitro drug sensitivity testing of tumor organoids to guide clinical medication strategies. The study involved a collection of 110 tissues from 71 cases of metastatic gastrointestinal cancers for organoids construction. A comprehensive analysis encompassed a testing of a total of 55 anticancer drugs. The study yielded compelling outcomes, demonstrating the remarkable effectiveness of organoid drug screening with 93% specificity, 100% sensitivity, 88% positive prediction rate, and 100% negative prediction rate. These results underscore an exceptionally high clinical relevance of the approach.
Single-cell Sequencing
Single-cell sequencing technologies are important tools utilized to understand the intricacies and heterogeneity of cellular populations and cellular systems. Cell-specific information gathered from these
Hangzhou AimingMed Technologies Co., Ltd.
